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View Full Version : Kea and Canine Cushing update


eas11
05-18-2006, 07:23 PM
Poor Kea! We thought things were going fairly well with her treatment for Cushings disease. After the loading period of the Lysodren, a dose of 3/8 of a pill 1x per week was prescribed. She did perk up, as well as decrease of the symptoms of excessive drinking (and peeing!). However, her skin began to get very dry about a month ago, and last week about an hour after giving her her weekly dose she began scratching uncontrollably, was VERY hyper for about 25 minutes and had diarrhea. Took her to the vet, by that time she was better, the vet thought it may be the lysodren or something else, and a coincidence. They did another stim test, and the vets at the office researched allergic reactions to lysodren as well, since the'd not seen/treated one. They found references on vet lists to allergic reactions like Kea had, and her stim test showed cortisol levels are up...meaning she'd need more lysodren :mad:

So, they want to switch her to Trilostane, which is not yet licenced/sold in this country legally other than a few compounding pharms (why? I don't understand how some can sell it?). The vet orders it to be sent to us. Kea seems sensitive to things and often has gastro or more minor itching as reactions, so the vets are a little concerned about anything new, really.

Although the Trilostane is not really cost prohibitive @ aprox 50.00 per month, she'll need the stim test (305.00 a pop) 3 times in the 1st 2 months and then every 4-6 months. Ouch!

We just want her to feel better :( She's still got gastro symptoms and is eating boiled rice and meat, still itching and seems...sad. She's sticking close to us all the time.

Any experience with Trilostane as treatment appreciated and I'll be looking for thoughts from our resident vet students as well.

TIA for good healing vibes sent Kea's way.

mcgeiger
05-19-2006, 06:33 AM
Trilostane, like many drugs, was approved elsewhere first (thanks for being so on top of stuff FDA...). It may well be the drug of choice in a few years if it becomes more widely advailable. The compounding pharmacies can make any drug that is not illegal. Manufacturers won't make products with limited markets, so anything not made for human needs a big demand to be made (like Rimadyl, heartgauard pluse, etc). For example, DES is BAD in humans, but can very sucessfully treat dogs for incontinence...
Anyway I'm sorry to hear that is hasn't been smooth sailing, I was actually thinking just the other day about pming you to ask...Good luck with new treatment!!!!