I cook Eye of Round roasts all the time, usually season them pretty plainly, though when I was a kid my dad would stud them with garlic to keep the vampires away. That's yummy too, but plain is nice as well.
I try to cook them no more than medium rare, because they aren't as tasty when cooked longer, IMHO.
A fruit is a vegetable with looks and money.
Plus, if you let fruit rot, it turns into wine,
something Brussels sprouts never do.
P. J. O'Rourke, humorist